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KMID : 0382619880080010543
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Hanyang Journal of Medicine
1988 Volume.8 No. 1 p.543 ~ p.551
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Effect of Dietary Beef Tallow and Corn Oil on Rat Liver
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Abstract
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The ingestion of lipid rich diets increases the plasma cholesterol, triglyceride and lipoprotein concentrations and it links to the development of coronary heart diseases. It has been suggested that the risk of coronary heart diseases is accelerated by the ingestion of saturated fatty acid and polysaturated fatty acid alters the hepatic lipid metabolism.
Therefore the author undertook the present study to investigate the effect of high polysaturated fatty acid on the lipid metabolism of the liver.
Sprague-Dawley albino rats weighing 100g were used as an experimental animals. The animals of the fat ingested groups were fed synthetic diets containing beef tallow and corn oil for 3 months. The experimental animals were killed at 1, 2 and 3 months after ingestion of dietary synthetic fat. The specimens obtained from the liver were fixed and stained with scarlet red for the lipid droplets in the hepatocytes.
The results were as follows.
1. The slight fat deposition was found on the hepatic lobule of the 1 and 2 month corn oil ingested groups and moderate fat deposition was observed in the periperal zone of the hepatic lobule of the 3 month corn oil ingested groups.
2. Moderate fat deposition on the liver of the 1 month beef tallow ingested groups and strong fat deposition on the liver of the 2 and 3 month beef´ fallow ingested groups were observed.
Consequently, it is suggested that ingestion of high polysaturated fatty acid would induce the fatty liver in the rat.
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